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The efficacy of Juliet Laser therapy

HISTOLOGICAL RESULTS

Histological studies show neocollagenogenesis and neoangiogenesis processes already visible in histological samples taken at 7 days after one treatment. All patients in this sample reported moreover after 7 days better vaginal lubrication, reduction / no dispareunia, better quality of sexual life and reduction in urinary urgency, frequency and urine loss.

Reference: University of Milan – Bicocca, San Gerardo Hospital, Monza, Italy – Department of Obstetrics and Gynecology

HISTOLOGICAL PREPARATION Hematoxylin & Eosin (200x)

The sample at day 0 shows an altered epithelium stratification with presence of cornification and superficial areas characterized by very low cellularity. The epithelium appears atrophic and a flattening of the dermal papillae at the dermoepidermal junction can be recognized.

At day 7 (after one treatment) the pavement epithelium appears well organized, with compact structure and presence of several nuclei, both in the deeper and superficial layers. The depth of the dermal papillae appears moreover increased, showing good tissue vitality.

30 days after 1 treatment Neocollagenogenesis and Angiogenesis processes are still visible and further widespread; a re-gained uniformity of the tissue is the evidence of efficient tissue regeneration.

In addition, the new collagen formation can be recognized through the white stripes visible in the deeper layers.

SEVERAL INTERNATIONAL STUDIES SHOW THE EFFICACY OF THE ERBIUM:YAG TECHNOLOGY IN THE TREATMENT of VAGINAL ATROPHY, LAXITY AND STRESS URINARY INCONTINENCE.

A German study of 84 patients with GSM and VVA symptoms showed that most patients (n = 58; 82%) reported positive treatment results. VHI and vaginal pH data were collected from the patients, and the average VHI and pH value showed statistically significant improvements after treatment.

Mothes AR, Runnebaum M, Runnebaum IB., An innovative dual-phase protocol for pulsed ablative vaginal Erbium:YAG laser treatment of urogynecological symptoms
Eur J Obstet Gynecol Reprod Biol. 2018 Oct;229:167-171

Another German study with 16 post-menopausal patients with a history of breast cancer and urogynaecological symptoms in combination with vaginal atrophy and pelvic floor dysfunction showed that the dual-phase protocol of vaginal Er:YAG laser application is effective and safe.

Mothes AR, Runnebaum M, Runnebaum IB. Ablative dual-phase Erbium:YAG laser treatment of atrophy-related vaginal symptoms in post-menopausal breast cancer survivors omitting hormonal treatment.
J Cancer Res Clin Oncol. 2018 May;144(5):955-960.

A prospective study from Germany of 33 women with mild to moderate urinary incontinence confirmed that vaginal Er:YAG laser therapy can improve the clinical condition and quality of life of the patients, in particular in view of target groups who require non-surgical treatment methods for SUI.

Reisenauer, C., Hartlieb, S., Schoenfisch, B. et al. Vaginal therapy of mild and moderate stress urinary incontinence using Er:YAG laser: a real treatment option.
Arch Gynecol Obstet 300, 1645–1650 (2019).

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